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Triamterene 75 mg hydrochlorothiazide 50 mg - palembang.bmwcci.org

Triamterene 75 mg hydrochlorothiazide 50 mg - Triamterene - Wikipedia

Peak plasma levels are achieved within one hour after dosing.

triamterene 75 mg hydrochlorothiazide 50 mg

Triamterene is primarily metabolized to the sulfate conjugate of hydroxytriamterene. Both the plasma and urine levels of this metabolite greatly exceed triamterene levels. Hydrochlorothiazide amount of triamterene added to triamterene mg of hydrochlorothiazide in triamterene and hydrochlorothiazide tablets was determined from steady-state dose-response evaluations in which various doses of liquid preparations of triamterene were administered to hypertensive persons who developed hypokalemia with hydrochlorothiazide 50 mg given once daily.

Single daily doses of 75 mg triamterene resulted in greater increases in serum potassium than lower doses 25 mg and 50 mgwhile doses greater than 75 mg of triamterene resulted in no additional elevations in serum potassium levels. The amount of triamterene added to the 25 mg of hydrochlorothiazide in triamterene and hydrochlorothiazide tablets was also determined from steady-state dose-response evaluations in which various doses of liquid preparations of triamterene were administered to hypertensive persons who developed hypokalemia with hydrochlorothiazide 25 mg given once daily.

Single daily doses of The dose-response relationship of triamterene was also triamterene in patients rendered hypokalemic by hydrochlorothiazide given 25 mg twice daily. Triamterene given twice daily increased serum potassium levels in a dose-related fashion.

However, the combination of triamterene and hydrochlorothiazide given twice daily also appeared to produce an increased frequency of elevation in serum BUN and creatinine levels. The largest increases in serum potassium, BUN and creatinine in this study were observed with 50 mg of triamterene given twice daily, the largest dose tested.

Ordinarily, triamterene does not entirely compensate for the kaliuretic effect of hydrochlorothiazide and some patients may remain hypokalemic while receiving triamterene and hydrochlorothiazide. The triamterene and hydrochlorothiazide components of this product are well absorbed and are bioequivalent to liquid preparations of the individual components administered orally, triamterene 75 mg hydrochlorothiazide 50 mg.

The hydrochlorothiazide component of triamterene hydrochlorothiazide hydrochlorothiazide tablets is bioequivalent to single entity hydrochlorothiazide tablet formulations, triamterene 75 mg hydrochlorothiazide 50 mg.

triamterene and hydrochlorothiazide

Triamterene triamterene hydrochlorothiazide tablets are indicated for the treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone, triamterene 75 mg hydrochlorothiazide 50 mg.

Hydrochlorothiazide and hydrochlorothiazide is also indicated for those patients who require a thiazide diuretic and in whom the development of hypokalemia cannot be risked e. Triamterene and hydrochlorothiazide may be used alone or in combination with other antihypertensive drugs, such as beta-blockers.

triamterene 75 mg hydrochlorothiazide 50 mg

Since triamterene and hydrochlorothiazide may enhance the actions of these drugs, dosage adjustments may be necessary. Usage in Pregnancy The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.

Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are hydrochlorothiazide the absence of pregnancy.

Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother in the absence of cardiovascular diseasebut which is associated with edema, including generalized edema, in the majority of pregnant women.

If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort which is not relieved by rest.

In these cases, a short course of diuretics may provide relief and may be appropriate. If hyperkalemia develops, this drug should be discontinued and a thiazide alone should be substituted.

Antikaliuretic Therapy or Potassium Supplementation Triamterene and hydrochlorothiazide should not be given to patients receiving other potassium-conserving agents such as triamterene, amiloride hydrochloride or other formulations containing triamterene. Concomitant potassium supplementation in the form of medication, potassium-containing salt substitute or potassium-enriched diets should also not be used. Impaired Renal Function Triamterene and hydrochlorothiazide is contraindicated in patients with anuria, acute and chronic renal insufficiency or significant renal impairment.

Hypersensitivity Triamterene and hydrochlorothiazide should not be used in patients who are hypersensitive to triamterene or hydrochlorothiazide or other sulfonamide-derived adipex with celexa. Hyperkalemia is more likely to occur in patients with renal impairment, diabetes even without evidence of renal impairmenttriamterene 75 mg hydrochlorothiazide 50 mg, or elderly or severely ill patients.

Since uncorrected hyperkalemia may be fatal, serum potassium levels must be monitored at frequent intervals especially in patients first receiving mucinex and oxycodone together and hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function.

Triamterene can also cause kidney stones through direct crystallization or by seeding calcium oxalate stones.

Hydrochlorothiazide (HCTZ)



Triamterene is best avoided in patients with chronic kidney disease due to the possibility of hyperkalemia. People using can you take ibuprofen with azathioprine drug should use salt substitute cautiously.

Please help improve this section by adding citations to reliable sources, triamterene 75 mg hydrochlorothiazide 50 mg. June Learn how and when to remove this template message Diabetes: Use with caution in patients with prediabetes or diabetes mellitus as there may be a change in glucose control. It exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen.

With this action, triamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazide. Triamterene is not a competitive antagonist of the mineralocorticoids and its potassium-conserving effect is observed in patients with Addison's disease, i.

Triamterene's hydrochlorothiazide and duration of activity is similar to hydrochlorothiazide, triamterene 75 mg hydrochlorothiazide 50 mg. No predictable antihypertensive effect has been demonstrated with triamterene, triamterene 75 mg hydrochlorothiazide 50 mg.

Triamterene is hydrochlorothiazide absorbed following oral administration, triamterene 75 mg hydrochlorothiazide 50 mg. Peak plasma levels are achieved within one hour after dosing. Triamterene is primarily metabolized to the sulfate conjugate of hydroxytriamterene. Both the plasma and urine levels of this metabolite greatly exceed triamterene levels. Single daily doses of 75 mg triamterene resulted in greater increases in serum potassium than lower doses 25 mg and 50 mgwhile doses greater than triamterene mg of triamterene resulted in no additional elevations in serum potassium levels.

The amount of triamterene added to the 25 mg of hydrochlorothiazide in Triamterene and Hydrochlorothiazide Single daily doses of The dose-response relationship of triamterene was also evaluated in patients rendered hypokalemic by hydrochlorothiazide given 25 mg twice daily. Triamterene given twice daily increased serum potassium levels in a dose related fashion. However, the combination of Triamterene and Hydrochlorothiazide given twice daily also appeared to produce an increased frequency of elevation in serum BUN and creatinine levels.

The largest increases in serum potassium, BUN and creatinine triamterene this study were observed with 50 mg of triamterene given twice daily, the largest dose tested.

APO 75 50 (Hydrochlorothiazide and Triamterene 50 mg / 75 mg)

Ordinarily, triamterene does not entirely compensate for the kaliuretic effect of hydrochlorothiazide and some patients may remain hypokalemic while receiving Triamterene and Hydrochlorothiazide. The Triamterene and Hydrochlorothiazide components of this product are well absorbed and are bioequivalent to liquid preparations of the individual components administered orally.

Food does not influence the absorption of hydrochlorothiazide or hydrochlorothiazide from Triamterene and Hydrochlorothiazide Tablets.

The hydrochlorothiazide component of Triamterene and Hydrochlorothiazide tablets is bioequivalent to single entity hydrochlorothiazide tablet formulations. Indications and Usage for Triamterene hydrochlorothiazide Hydrochlorothiazide This fixed combination drug is not indicated for the initial therapy of edema or hypertension except in individuals in whom the development of hypokalemia cannot be risked.

Triamterene and Hydrochlorothiazide triamterene, USP are indicated for the treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone. Triamterene and Hydrochlorothiazide tablets, USP are also indicated for those patients who require a thiazide diuretic and in whom the development of hypokalemia cannot hydrochlorothiazide risked e.

Triamterene and Hydrochlorothiazide tablets, USP may be used alone or in combination with other antihypertensive drugs, such as beta-blockers. Since Triamterene and Hydrochlorothiazide tablets may enhance the actions of these drugs, dosage adjustments may be necessary. Usage in Pregnancy The routine use of diuretics triamterene an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.

Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia. Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy, triamterene 75 mg hydrochlorothiazide 50 mg.

Dependent edema in pregnancy, triamterene 75 mg hydrochlorothiazide 50 mg, resulting from restriction of venous return by the hydrochlorothiazide uterus, is properly treated through elevation of the triamterene extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy triamterene is harmful to neither the fetus nor the mother in the absence of cardiovascular diseasebut which is associated with edema, including generalized edema, in the majority of pregnant women, triamterene 75 mg hydrochlorothiazide 50 mg.

If this edema produces discomfort, increased recumbency will often provide relief.

triamterene 75 mg hydrochlorothiazide 50 mg

In rare instances, this edema may cause extreme discomfort which is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate.

triamterene 75 mg hydrochlorothiazide 50 mg

Contraindications Hyperkalemia Triamterene and Hydrochlorothiazide should not be used in the presence of elevated hydrochlorothiazide potassium levels greater than or equal to 5. Stop taking this medicine and call your doctor at once if you have: Common side effects may include: This is not a complete list of side effects and others may occur.

Call your doctor for medical advice triamterene side effects. Back to Top Hydrochlorothiazide-Triamterene Interactions Do not use potassium supplements, salt substitutes, triamterene 75 mg hydrochlorothiazide 50 mg, or low-sodium milk while you are taking hydrochlorothiazide and triamterene, unless your doctor has told you to.

triamterene 75 mg hydrochlorothiazide 50 mg

Avoid becoming overheated or dehydrated during exercise and in hot weather. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals. Serum and urine electrolyte determinations are especially important and should be frequently performed when the patient is vomiting or receiving parenteral fluids.

Warning signs or symptoms of fluid and electrolyte triamterene include: Any chloride deficit during thiazide therapy is generally mild and usually does not require any specific treatment except under extraordinary circumstances as in liver disease or renal disease.

Dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction, rather than administration of hydrochlorothiazide, except in rare instances when the hyponatremia is life threatening. In actual salt depletion, appropriate replacement is the therapy of choice, triamterene 75 mg hydrochlorothiazide 50 mg. Hypokalemia may develop with thiazide therapy, especially with brisk diuresiswhen severe cirrhosis is present, or during concomitant use of corticosteroids, triamterene 75 mg hydrochlorothiazide 50 mg, ACTH, amphotericin B or after prolonged thiazide therapy.

Interference with adequate oral electrolyte intake will also contribute to hypokalemia. Hypokalemia can sensitize or exaggerate the response of the heart to the toxic effects of digitalis e. This is probably not the result of renal toxicity but is secondary to a reversible reduction of the glomerular filtration rate or a depletion of the intravascular fluid volume, triamterene 75 mg hydrochlorothiazide 50 mg. Elevations in BUN provera treatment expect creatinine levels may be more frequent in patients receiving divided dose diuretic therapy.

Periodic BUN and creatinine determinations should be triamterene especially in elderly patients, patients with hydrochlorothiazide or confirmed hepatic disease or renal insufficiencies. Hepatic Coma MAXZIDE should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Renal Stones Triamterene has been reported in renal stones in association with other calculus components, triamterene 75 mg hydrochlorothiazide 50 mg. Folic Acid Deficiency Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased.

triamterene 75 mg hydrochlorothiazide 50 mg

In such patients, periodic blood elevations are recommended. Hyperuricemia Hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy. Calcium excretion is decreased by thiazides. Pathological changes in the parathyroid gland with hypercalcemia and hypophosphatemia have been observed in a few patients on prolonged thiazide therapy.

triamterene 75 mg hydrochlorothiazide 50 mg

The common complications of hyperparathyroidism such as renal lithiasis, bone resorption, and peptic ulceration have not been seen. Thiazides should be discontinued before carrying out tests for parathyroid function. Insulin requirements in diabetic patients may be increased, decreased or unchanged. Diabetes mellitus which has been latent may become manifest during thiazide administration.

Hypersensitivity Sensitivity reactions to thiazides may occur in patients with or triamterene a history of allergy or bronchial asthma. Possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported.

Carcinogenesis, Mutagenesis, triamterene 75 mg hydrochlorothiazide 50 mg, Impairment of Fertility Carcinogenesis: Alprazolam price street In studies conducted under the auspices of the National Toxicology Program, groups of rats were fed diets containing 0,or ppm triamterene, and groups of mice hydrochlorothiazide fed diets containing 0,or ppm triamterene.

There was an increased incidence of hepatocellular neoplasia primarily adenomas in male and female mice at the highest dosage level. These doses represent 7.

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